Reactions of polyfluorobenzenes with nucleophilic reagents

Microwave assisted condensation reactions of 2-aryl hydrazonopropanals with nucleophilic reagents and dimethyl acetylenedicarboxylate.

The reaction of methyl ketones 1a-g with dimethylformamide dimethylacetal (DMFDMA) afforded the enaminones 2a-g, which were coupled with diazotized aromatic amines 3a,b to give the corresponding aryl hydrazones 6a-h. Condensation of compounds 6a-h with some aromatic heterocyclic amines afforded iminoarylhydrazones 9a-m. Enaminoazo compounds 12a,b could be obtained from condensation of 6c with s...

Reactions of iodine-nitrene reagents with boranes.

Reactions of the boranes (C6F5)2BR (R = C6F5, Ph, H) with the nitrene-iodine reagents XC6H4SO2N=IPh, X = Me, Cl and MeSO2N=IPh effect the insertion of nitrene into the B–C and B–H bonds affording the species (C6F5)2BN(SO2C6H4X)R (X = Me, R = C6F5 1, Ph 3, H, 4, X = Cl, 5, X = NO2, 7) and (C6F5)2BN(SO2Me)H 6).

Antigen – Antibody Reactions with Labeled Reagents

Nucleophilic substitution reactions of pyranose polytosylates.

The 2,3,4-tri-toluenesulfonate ester derivatives of the methyl pyranosides of l-arabinose, d-ribose, d-lyxose, and d-xylose have been prepared, and their substitution reactions with various nucleophiles have been examined. For arabinose, xylose, and ribose, highly regioselective monosubstitutions were observed with benzoate, nitrite, and azide anions. These reactions have led to short and simpl...

Nucleophilic Substitution Reactions of α-Bromoacetanilides with Benzylamines

Kinetic studies of the reactions of α-bromoacetanilides [YC6H4NHC(=O)CH2Br] with substituted benzylamines (XC6H4CH2NH2) have been carried out in dimethyl sulfoxide at 35.0 C. The Hammett plots for substituent (Y) variations in the substrate (log kN vs. σY) are biphasic concave upwards/downwards with breaks at Y = 4-Cl (σY = 0.23). The Hammett coefficients ρY and the cross-interaction constant ρ...